Nursing Medication Card - Lactulose (Kor/Eng)

 

Lactulose

• 적응증: 만성 변비, 간성 뇌증
• 작용 기전: 장내 pH 감소로 암모니아 흡수 억제, 삼투 작용으로 배변 유도
• 흡수 및 대사: 경구 투여 후 대장에서 박테리아에 의해 대사
• 부작용: 복부 팽만감, 가스, 설사
• 투여량: 변비: 15-30mL/일, 간성 뇌증: 30-45mL를 1시간 간격으로 투여하여 2-3회의 연한 변 유도
• 간호 고려사항: 수분 섭취 권장, 전해질 불균형 모니터링

Lactulose  laxatives/osmotics 

● Indications: treatment of chronic constipation, adjunct in management of portal-systemic encephalopathy(PSE) ● Therapeutic effects: relief of constipation, decreased blood ammonia lvls w/ improved mental status in PSE ● Absorption: <3% ac PO

● Distribution: unknown 

● Metabolism&Excretion: absorbed lactulose excreted unchanged in urine, unabsorbed is metabolized by colonic bacteria to lactic, acetic, and formic acids 

● ADE: GI; belching, cramps, distention, flatulence Endo; hyperglycemia (DM patient) 

● Dose: PO; 15-30ml/day upto 60ml as liquid, or 10-20g as powder upto 40g for constipation 

Lactulose

• Indications: Constipation, hepatic encephalopathy
• Therapeutic Effects: Reduces ammonia absorption; osmotic laxative
• Absorption: <3% absorbed orally
• Distribution: Unknown
• Metabolism & Excretion: Metabolized by colonic bacteria; excreted in feces
• ADEs: Flatulence, abdominal cramps, diarrhea
• Dose: 15–30 mL/day for constipation; higher for encephalopathy
• Considerations: Monitor electrolytes in long-term use WebMD+2RxList+2DrugBank+2Nursing Central