Nursing Medication Card - Acetaminophen (Kor/Eng)

Nursing Medication Card – Acetaminophen

약물명 (Drug Name): Acetaminophen (아세트아미노펜)
상품명 (Brand Names): Tylenol, Tempra, Paracetamol 등
약물분류 (Class): Non-opioid analgesic / Antipyretic
비마약성 진통‧해열제

구분 (Category)핵심 정보 (Key Points)

Indications (적응증)	• Mild-to-moderate pain & fever (경증-중등도 통증·발열) • Post-vaccination fever/pain (예방접종 후 발열·통증) • Combined with opioids for moderate-to-severe pain (중-중증 통증 시 오피오이드 병용)
Therapeutic Effects (치료 효과)	• Central COX inhibition → ↓ Prostaglandin in CNS • Analgesia & antipyresis without significant anti-inflammatory action
Absorption (흡수)	• PO: well absorbed; onset 30–60 min • PR: variable absorption • IV: 100 % bio­avail., onset ≤ 30 min
Distribution (분포)	• Widely distributed; crosses placenta • Low protein binding (~10–25 %) • Low amounts enter breast milk
Metabolism & Excretion (대사·배설)	• ~ 90 % hepatic conjugation (glucuronidation, sulfation) • ~ 5–10 % CYP2E1 → toxic metabolite (NAPQI) detoxified by glutathione • Renal excretion of metabolites • t½ ≈ 2–3 h (↑ in overdose or liver disease)
Adverse Drug Effects (부작용)	Common: Rare at therapeutic dose Serious: Hepatotoxicity (overdose), acute liver failure, severe skin reactions (SJS/TEN, AGEP)
Dose (용량)	Adults (≥ 50 kg): • PO/PR: 325–650 mg q4–6 h OR 1 g q6–8 h (MAX 4 g/24 h)* • IV: 1 g q6 h OR 650 mg q4 h (MAX 4 g/24 h) Liver impairment / chronic ETOH / older adults: MAX 2 g/24 h
Nursing Considerations (간호 고려사항)	• Liver safety: Review total daily dose (OTC combos!) → monitor AST/ALT in long-term use or high risk patients. • Overdose: Antidote = N-acetylcysteine (NAC); watch for nausea, RUQ pain, ↑ LFTs. • Avoid alcohol & other hepatotoxins. • Safe in pregnancy at recommended doses (Category B). • Educate patient: many cold/flu remedies contain acetaminophen—check labels!

 

*일반 성인 최대 4 g/일, 간질환·고령·알코올 남용자는 2 g/일로 제한 권장

 

Acetaminophen (Tylenol) 

Antipyretics, nonopioid analgesics 

● Indications: treatment of mild pain, fever (PO, Rect), treatment of mild to moderate pain, moderate to severe pain w/o opioid analgesics, fever. 

● Therapeutic effects: analgesia, antipyresis 

● Absorption: well absorbed after PO. Rect variable. IV > complete bioavailability. 

● Distribution: wide. Cross placenta, enter breast milk in low concentrations. 

● Metabolism&Excretion: 85-95% metabolized by liver. Metabolites may be toxic in overdose. Excreted by kidneys.

● Onset/Peak/Duration: PO: onset 0.5-1hr, Peak; 1-3hr, Duration; 3-8 hr Rect: Onset; 0.5-1hr, Peak; 1-3hr, Duration; 3-4hr, IV: Onset; within 30mins, Peak; 30min, Duration; 4-6hr 

● ADE: Derm: acute generalized exanthematous pustulosis, stevens-johnson syndrome, toxic epidermal, necrolysis GI: hepatotoxicity (high doses) 

● Dose: PO: 325-650 mg Q6H or 1g 3-4/day or 1300 mg Q8H (don’t exceed 3g or 2g/24hr if hepatic, renal impairment), IV: 1g Q6H or 650mg Q4H (no exceed 1g/dose, 4g/day by all routes)